Sensitization may develop following the topical application of this drug. Signs of local irritations with subjective symptoms of itching and burning, angioneurotic edema, urticaria, vesicular and maculopapular dermatitis have been reported in patients sensitive to chloramphenicol. Discontinue use immediately. Prolonged use of antibiotics may occasionally result in overgrowth of nonsusceptible organisms including fungi. If this occurs, discontinue chloramphenicol eye drops and institute appropriate treatment. Systemic chloramphenicol has been known to produce bone marrow hypoplasia, depression of erythropoiesis and aplastic anemia and visual disturbances.
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